Project #1: Stump project
Before we can regenerate an entire limb, can we at least regenerate the thick type of skin of our palms and soles (“volar” skin) at the stump site of an amputee?
We are currently focusing on cellular therapy and the ability of fibroblasts to modulate the function of neighboring keratinocytes. Here we focus on questions relating to cell-cell communication, cellular engraftment, and mechanisms for tissue identity maintenance. Our work is culminating in an FDA approved trial using cellular therapy in normal human subjects and amputees to modify skin identity.